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. 2010 May;30(5):449-53.
doi: 10.1002/pd.2496.

First trimester maternal serum placental growth factor in trisomy 21 pregnancies

N J Cowans  1 , A Stamatopoulou, K Spencer
Affiliations

First trimester maternal serum placental growth factor in trisomy 21 pregnancies

N J Cowans et al. Prenat Diagn. 2010 May.

Abstract

Objective: To examine placental growth factor (PlGF) levels in first trimester maternal serum in trisomy 21 pregnancies and to investigate the potential value of PlGF in a first trimester screening test.

Methods: First trimester maternal serum from 70 trisomy 21 cases and 375 euploid controls were retrospectively analyzed for PlGF using a DELFIA Xpress immunoassay platform. Results were expressed as multiples of medians (MoM) for comparison.

Results: PlGF levels were significantly decreased in pregnancies with trisomy 21, 0.76 MoM versus 0.98 MoM in controls. Inclusion of PlGF into the first trimester combined test [maternal age, pregnancy associated plasma protein-A (PAPP-A), free-beta human chorionic gonadotrophin (beta-hCG) and nuchal translucency] would increase the detection rate by 0.5% at a 5% false positive rate.

Conclusion: PlGF at 11 weeks to 13 weeks 6 days has the potential to be included as a marker for the detection of pregnancies with trisomy 21.

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