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Review

Glycosylation Precursors

Hudson H Freeze, Alan D Elbein
Ajit Varki, Richard D Cummings, Jeffrey D Esko, Hudson H Freeze, Pamela Stanley, Carolyn R Bertozzi, Gerald W Hart, Marilynn E Etzler
, editors.
In: Essentials of Glycobiology. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 4.
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Review

Glycosylation Precursors

Hudson H Freeze et al.
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Excerpt

Glycoconjugate biosynthesis requires activation of monosaccharides to nucleotide sugars. Monosaccharides are imported into the cell, salvaged from degraded glycans, or derived from other sugars within the cell. Although most glycosylation reactions occur in the Golgi, precursor activation and interconversions occur mostly in the cytoplasm. nucleotide sugar–specific transporters carry the activated donors into the Golgi. This chapter describes how eukaryotic cells accomplish these tasks.

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References

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