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Review

Dilated Cardiomyopathy Overview

Ray E Hershberger  1 , Elizabeth Jordan  2
Margaret P Adam, Sarah Bick, Ghayda M Mirzaa, Roberta A Pagon, Stephanie E Wallace, Anne Amemiya
, editors.
In: GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993.
[updated ].
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Free Books & Documents
Review

Dilated Cardiomyopathy Overview

Ray E Hershberger et al.
Free Books & Documents

Excerpt

The purpose of this overview is to:

  1. 1

    Define DCM;

  2. 2

    Identify the categories of DCM;

  3. 3

    Provide the evaluation strategy of a proband with nonsyndromic DCM;

  4. 4

    Provide a basic view of genetic risk assessment of at-risk asymptomatic relatives of a proband with DCM to inform cardiac surveillance and allow early detection and treatment of DCM to improve long-term outcome.

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References

    1. Alkhunaizi E, Martin N, Jelin AC, Rosner M, Bailey DJ, Steiner LA, Lakhani S, Ji W, Katzman PJ, Forster KR, Jarinova O, Shannon P, Chitayat D; Care4Rare Canada Consortium. Fetal akinesia deformation sequence syndrome associated with recessive TTN variants. Am J Med Genet A. 2023;191:760-9. - PMC - PubMed
    1. Burkett EL, Hershberger RE. Clinical and genetic issues in familial dilated cardiomyopathy. J Am Coll Cardiol. 2005;45:969-81. - PubMed
    1. Caleshu C, Day S, Rehm HL, Baxter S. Use and interpretation of genetic tests in cardiovascular genetics. Heart. 2010;96:1669-75. - PubMed
    1. Cowan JR, Kinnamon DD, Morales A, Salyer L, Nickerson DA, Hershberger RE. Multigenic disease and bilineal inheritance in dilated cardiomyopathy is illustrated in nonsegregating LMNA pedigrees. Circ Genom Precis Med. 2018;11:e002038. - PMC - PubMed
    1. Dellefave L, McNally EM. The genetics of dilated cardiomyopathy. Curr Opin Cardiol. 2010;25:198-204. - PMC - PubMed

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