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Review

Uncomplicated (Pure) Hereditary Spastic Paraplegia Overview

Peter Hedera  1
Margaret P Adam, Jerry Feldman, Ghayda M Mirzaa, Roberta A Pagon, Stephanie E Wallace, Anne Amemiya
, editors.
In: GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993.
[updated ].
Affiliations
Free Books & Documents
Review

Uncomplicated (Pure) Hereditary Spastic Paraplegia Overview

Peter Hedera.
Free Books & Documents

Excerpt

The purpose of this overview is to:

  1. 1

    Briefly describe the clinical characteristics of uncomplicated (pure) hereditary spastic paraplegia;

  2. 2

    Review the genetic causes of uncomplicated hereditary spastic paraplegia;

  3. 3

    Review the differential diagnosis of uncomplicated hereditary spastic paraplegia, which includes complicated hereditary spastic paraplegia with a focus on treatable genetic disorders;

  4. 4

    Provide an evaluation strategy to identify the genetic cause of uncomplicated hereditary spastic paraplegia in a proband (when possible);

  5. 5

    Review management of uncomplicated hereditary spastic paraplegia;

  6. 6

    Inform genetic counseling of family members of an individual with uncomplicated hereditary spastic paraplegia.

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