Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2010 Mar-Apr;32(2):228.e9-228.e10.
doi: 10.1016/j.genhosppsych.2009.04.010. Epub 2009 Jun 9.

Marfan syndrome and schizophrenia: a case report and literature review

Mary Lemberg  1 , Alexander W Thompson
Affiliations
Case Reports

Marfan syndrome and schizophrenia: a case report and literature review

Mary Lemberg et al. Gen Hosp Psychiatry. 2010 Mar-Apr.

Abstract

Introduction: Marfan Syndrome (MFS), a disease of microfibril dysfunction, has been associated with schizophrenia in multiple case reports.

Case report: We present one case and review the literature that suggests these conditions may share a common etiologic pathway.

Discussion: A possible underlying mechanism of both schizophrenia and MFS is the abnormal expression of growth factors and signaling cascades.

Conclusion: MFS patients should be monitored for psychiatric symptoms and patients with signs of MFS should be referred for appropriate medical care. Also, by understanding shared mechanisms, we may develop better understanding and treatments.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Dean JC. Marfan syndrome: clinical diagnosis and management. Eur J Hum Genet. 2007;15(7):724–733. - PubMed
    1. Ramirez F, Carta L, Lee-Arteaga S. Fibrillin-Rich Microfibrils - Structural and Instructive Determinants of Mammalian Development and Physiology. Connect Tissue Res. 2008;49(1):1–6. - PubMed
    1. Dietz HC, Cutting GR, Pyeritz RE, et al. Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene. Nature. 1991;352(6333):337–339. - PubMed
    1. De Paepe A, Devereux RB, Dietz HC, Hennekam RC, Pyeritz RE. Revised diagnostic criteria for the Marfan syndrome. Am J Med Genet. 1996;62(4):417–426. - PubMed
    1. Pyeritz RE. Marfan syndrome and other disorders of fibrillin. In: Rimoin D, Conner J, Pyeritz RE, editors. Principles and Practice of Medical Genetics. 3 ed. New York: Churchill Livingstone; 1997.

Publication types