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. 2010 Jul;120(1-3):71-5.
doi: 10.1016/j.schres.2010.02.1067. Epub 2010 Mar 20.

Subjective rating of working memory is associated with frontal lobe volume in schizophrenia

Matthew A Garlinghouse  1 , Robert M Roth, Peter K Isquith, Laura A Flashman, Andrew J Saykin
Affiliations

Subjective rating of working memory is associated with frontal lobe volume in schizophrenia

Matthew A Garlinghouse et al. Schizophr Res. 2010 Jul.

Abstract

Background: Patients with schizophrenia commonly show deficits in working memory on objective neuropsychological measures, and brain imaging studies have documented neural abnormalities during performance of working memory tasks. It remains unclear to what extent such patients are able to accurately gauge the integrity of their working memory in their daily lives.

Aims: We evaluated the relationship between subjective rating of working memory integrity in daily life and volumes of the frontal, temporal, and parietal lobes in patients with schizophrenia.

Methods: Participants included 29 patients with schizophrenia and 26 healthy comparison subjects. Participants completed a structural magnetic resonance imaging (MRI) scan, the Self Report form of the Behavioral Rating Inventory of Executive Function - Adult version (BRIEF-A), and Digit Span Backwards as an objective measure of working memory. Lobar volumes were obtained using an automated processing package and adjusted for total intracranial volume.

Results: The patient group reported worse working memory in daily life, and performed worse on Digit Span Backwards, than the comparison group. Within the patient group, poorer working memory in daily life was associated with smaller left and right frontal lobe volumes. Shorter backwards digit span was associated with smaller left frontal and left and right temporal lobe volumes.

Conclusions: The significant relationship between frontal lobe volumes and subjective working memory in daily life provides some support for the validity of self report measures of cognitive functioning in patients with schizophrenia, and provides further evidence for a contribution of frontal lobe abnormality to executive dysfunction in the illness.

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Conflict of interest statement

Conflict of interest

RMR and JKI are authors of the Behavior Rating Inventory of Executive Function – Adult version and receive a royalty from the publisher. The authors declare no other conflict of interest related to the content of this article.

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