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. 2010 Apr 1;18(7):2402-11.
doi: 10.1016/j.bmc.2010.02.057. Epub 2010 Mar 2.

Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton

Masahiko Nakamura  1 , Atsushi Aoyama, Mohammed T A Salim, Mika Okamoto, Masanori Baba, Hiroyuki Miyachi, Yuichi Hashimoto, Hiroshi Aoyama
Affiliations

Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton

Masahiko Nakamura et al. Bioorg Med Chem. .

Abstract

A phenanthridinone skeleton was derived from our previous researches on thalidomide and retinoids as a multi-template for generation of anti-viral lead compounds. Structural development studies focusing on anti-hepatitis C virus activity afforded 5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6(5H)-one (10) and 5-butylbenzo[b]phenanthridin-6(5H)-one (39), which showed EC(50) values of approximately 3.7 and 3.2microM, respectively.

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