Tumor delivery of macromolecular drugs based on the EPR effect
- PMID: 20304019
- DOI: 10.1016/j.addr.2010.03.011
Tumor delivery of macromolecular drugs based on the EPR effect
Abstract
Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This specific issue of Advanced Drug Delivery Reviews is summing up multiple data on the EPR effect-based drug design and clinical outcome. In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors.
Copyright © 2010 Elsevier B.V. All rights reserved.
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