This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comment

. 2010 Mar 30;107(13):5701-2.

doi: 10.1073/pnas.1001503107. Epub 2010 Mar 16.

Keeping sphingolipid levels nORMal

Tobias C Walther¹

Affiliations

PMID: 20304791
PMCID: PMC2851878
DOI: 10.1073/pnas.1001503107

Comment

Keeping sphingolipid levels nORMal

Tobias C Walther. Proc Natl Acad Sci U S A. 2010.

. 2010 Mar 30;107(13):5701-2.

doi: 10.1073/pnas.1001503107. Epub 2010 Mar 16.

Author

Tobias C Walther¹

Affiliation

¹ Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany. twalther@biochem.mpg.de

PMID: 20304791
PMCID: PMC2851878
DOI: 10.1073/pnas.1001503107

No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1. — Fig. 1.
Model of the homeostatic regulation of SPT activity by Orm proteins. See text for details.

See this image and copyright information in PMC

Comment on

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control.
Han S, Lone MA, Schneiter R, Chang A. Han S, et al. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5851-6. doi: 10.1073/pnas.0911617107. Epub 2010 Mar 8. Proc Natl Acad Sci U S A. 2010. PMID: 20212121 Free PMC article.

Similar articles

Orm family proteins mediate sphingolipid homeostasis.
Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman JS. Breslow DK, et al. Nature. 2010 Feb 25;463(7284):1048-53. doi: 10.1038/nature08787. Nature. 2010. PMID: 20182505 Free PMC article.
Orm proteins integrate multiple signals to maintain sphingolipid homeostasis.
Gururaj C, Federman RS, Chang A. Gururaj C, et al. J Biol Chem. 2013 Jul 12;288(28):20453-63. doi: 10.1074/jbc.M113.472860. Epub 2013 Jun 4. J Biol Chem. 2013. PMID: 23737533 Free PMC article.
Cell biology: A brake on lipid synthesis.
Tafesse FG, Holthuis JC. Tafesse FG, et al. Nature. 2010 Feb 25;463(7284):1028-9. doi: 10.1038/4631028a. Nature. 2010. PMID: 20182499 No abstract available.
Orm/ORMDL proteins: Gate guardians and master regulators.
Davis D, Kannan M, Wattenberg B. Davis D, et al. Adv Biol Regul. 2018 Dec;70:3-18. doi: 10.1016/j.jbior.2018.08.002. Epub 2018 Aug 31. Adv Biol Regul. 2018. PMID: 30193828 Free PMC article. Review.
Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae.
Funato K, Vallée B, Riezman H. Funato K, et al. Biochemistry. 2002 Dec 24;41(51):15105-14. doi: 10.1021/bi026616d. Biochemistry. 2002. PMID: 12484746 Review. No abstract available.

See all similar articles

Cited by

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.
Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J. Roelants FM, et al. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19222-7. doi: 10.1073/pnas.1116948108. Epub 2011 Nov 11. Proc Natl Acad Sci U S A. 2011. PMID: 22080611 Free PMC article.
Arabidopsis 56-amino acid serine palmitoyltransferase-interacting proteins stimulate sphingolipid synthesis, are essential, and affect mycotoxin sensitivity.
Kimberlin AN, Majumder S, Han G, Chen M, Cahoon RE, Stone JM, Dunn TM, Cahoon EB. Kimberlin AN, et al. Plant Cell. 2013 Nov;25(11):4627-39. doi: 10.1105/tpc.113.116145. Epub 2013 Nov 8. Plant Cell. 2013. PMID: 24214397 Free PMC article.
Plasma Membrane Proteolipid 3 Protein Modulates Amphotericin B Resistance through Sphingolipid Biosynthetic Pathway.
Bari VK, Sharma S, Alfatah M, Mondal AK, Ganesan K. Bari VK, et al. Sci Rep. 2015 May 12;5:9685. doi: 10.1038/srep09685. Sci Rep. 2015. PMID: 25965669 Free PMC article.
Transmembrane transporter expression regulated by the glucosylceramide pathway in Cryptococcus neoformans.
Singh A, Rella A, Schwacke J, Vacchi-Suzzi C, Luberto C, Del Poeta M. Singh A, et al. BMC Res Notes. 2015 Nov 16;8:681. doi: 10.1186/s13104-015-1613-y. BMC Res Notes. 2015. PMID: 26572681 Free PMC article.
Sphingolipids activate the endoplasmic reticulum stress surveillance pathway.
Piña F, Yagisawa F, Obara K, Gregerson JD, Kihara A, Niwa M. Piña F, et al. J Cell Biol. 2018 Feb 5;217(2):495-505. doi: 10.1083/jcb.201708068. Epub 2018 Jan 9. J Cell Biol. 2018. PMID: 29317528 Free PMC article.

See all "Cited by" articles

References

1. Breslow DK, et al. Orm family proteins mediate sphingolipid homeostasis. Nature. 2010;463:1048–1053. - PMC - PubMed
1. Han S, Lone MA, Schneiter R, Chang A. Orm1 and Orm2 are conserved ER membrane proteins regulating lipid homeostasis and protin quality control. Proc Natl Acad Sci USA. 2010;107:5851–5856. - PMC - PubMed
1. Hjelmqvist L, Tuson M, Marfany G, Herrero E, Balcells S, Gonzalez-Duarte R. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 2002 3:RESEARCH0027. - PMC - PubMed
1. Aronova S, et al. Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab. 2008;7:148–158. - PMC - PubMed
1. Zhang X, Lester RL, Dickson RC. Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p. J Biol Chem. 2004;279:22030–22038. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Molecular Biology Databases
- Saccharomyces Genome Database