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. 2009 Jan 1:19:4655-4672.
doi: 10.1039/b817667c.

Multifunctional Nanoparticles as Biocompatible Targeted Probes for Human Cancer Diagnosis and Therapy

Ken-Tye Yong  1 , Indrajit Roy, Mark T Swihart, Paras N Prasad
Affiliations

Multifunctional Nanoparticles as Biocompatible Targeted Probes for Human Cancer Diagnosis and Therapy

Ken-Tye Yong et al. J Mater Chem. .

Abstract

The use of nanoparticles in biological application has been rapidly advancing toward practical applications in human cancer diagnosis and therapy. Upon linking the nanoparticles with biomolecules, they can be used to locate cancerous area as well as for traceable drug delivery with high affinity and specificity. In this review, we discuss the engineering of multifunctional nanoparticle probes and their use in bioimaging and nanomedicine.

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Figures

Figure 1
Figure 1
Emission spectra for different sizes of CdSe QDs. The CdSe QDs size decreases as the emission peak blue shifted.
Figure 2
Figure 2
TEM image of CdSe/CdS/ZnS QDs. The size is ~6 nm. The scale bar is 100 nm.
Figure 3
Figure 3
TEM image of InP/ZnS QDs.
Figure 4
Figure 4
TEM image of CdTe/ZnTe QDs
Figure 5
Figure 5
Emission spectra for different sizes of CdTe/ZnTe QDs. The CdTe/ZnTe QDs size increases as the emission peak red shifted.
Figure 6
Figure 6
Size-dependent optical properties of aqueous dispersion of CdTe/ZnTe QDs, demonstrating quantum confinement and size-tunable luminescent emission.
Figure 7
Figure 7
HTREM image of silicon QDs.
Figure 8
Figure 8
TEM image of PbSe QRs. The scale bar is 200 nm.
Figure 9
Figure 9
TEM image of CdS QRs. The scale bar is 100 nm.
Figure 10
Figure 10
TEM image of CdSe/CdS/ZnS QRs. The scale bar is 70 nm.
Figure 11
Figure 11
TEM image of monodispersed SiO2 coated QR nanoparticle. The average size is 40 nm. The scale bar is 100 nm.
Figure 12
Figure 12
Confocal image of macrophage cells treated with SiO2 coated QR particles.
Figure 13
Figure 13
TEM image of gold NRs.
Figure 14
Figure 14
Visible absorption spectra of gold NRs with different aspect ratio.
Figure 15
Figure 15
Scattering image of gold NRs with different aspect ratio.
Figure 16
Figure 16
Confocal images of Panc-1 cells treated with rhodamine-B-conjugated ORMOSIL NPs, without (a) and with (b) bioconjugation with anti-claudin-4.
Figure 17
Figure 17
Confocal microscopy images of MiaPaCa cells labeled with unconjugated (lysine-coated) (a, b, and c), and transferrin-conjugated (d, e, and f) CdSe/CdS/ZnS QRs. The images to the left (a and d) show tranmission images. The corresponding fluorescence images are shown in (b) and (e), and overlays of the two are shown in (c) and (f).
Figure 18
Figure 18
Confocal image of pancreatic cancer cells labeled with anti-mesothelin conujugated CdSe/ZnTe QDs (overlay of transmission and fluorescence images).
Figure 19
Figure 19
Confocal image of pancreatic cell lines labeled with CdSe/CdS/ZnS quantum rod bioconjugates.
Figure 20
Figure 20
Cytotoxicity studies of Panc-1, HeLa, and KB cells treated with drug-QRs probe. MTT assays illustrating cell viability upon exposing the cells with different concentration of drug bioconjugates for 24 hours.
Figure 21
Figure 21
in vivo fluorescence image of a mouse treated with phospholipid micelle encapsulated near-IR CdTeSe QDs. The NIR QDs were injected sub-Q under the brain area of the mouse. The red and green colors correspond to the luminescence from the QDs and autofluorescence from the mouse, respectively.
Figure 22
Figure 22
In vivo fluorescence image of a tumor-bearing mouse using anti-claudin-4 conjugated CdSe/CdS/ZnS QRs as early cancer detection probe.
Figure 23
Figure 23
Dark-field scattering images from Panc-1 cells following (a) treatment with anti-mesothelin-conjugated gold NRs and (b) no treatment. The wavelength selective scattering (orange/red) associated with the NRs can be clearly distinguished from the background, and corresponds to the longitudinal surface plasmon oscillation in the red region of the optical spectrum.
Figure 24
Figure 24
TEM images of Panc-1 cells following (a) treatment with anti-mesothelin-conjugated gold NRs and (b) no treatment.
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