Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jan;11(1):1-3.
doi: 10.2174/138920010791110908.

Update information on drug metabolism systems--2009, part I

F Peter Guengerich  1 , Slobodan Rendic
Affiliations
Review

Update information on drug metabolism systems--2009, part I

F Peter Guengerich et al. Curr Drug Metab. 2010 Jan.

Abstract

The field of drug metabolism has changed dramatically in the past generation. Two of the driving forces are the advances in analytical chemistry and our understanding of the biological systems. With regard to the former, the advances in liquid chromatography-mass spectrometry (LC-MS) are extremely impressive, and the speed of analysis has been increased even more with the recent developments in ultraperformance LC (UPLC). NMR analysis on a sub-microgram scale is not unusual, and the 2-dimensional methods are also very impressive. The biology underlying gene regulation is highly developed, and the recombinant methods have greatly facilitated progress in the field. Today it is common to design discovery and development efforts focused on critical human phenomena from the very start, with animal studies supporting the efficacy and safety efforts.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Guengerich FP. Update information on human P450s. Drug Metab Rev. 2002;34(1–2):7–15. - PubMed
    1. Dean M, Rzhetsky A, Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 2001;11(7):1156–1166. - PubMed
    1. Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological pathological and therapeutic implications of human membrane transport proteins: Introduction. Plugers Arch. 2004;447(5):465–468. - PubMed
    1. Ho RH, Kim RB. Uptake transporters. In: Guengerich FP, McQueeen CA Series Ed, editors. Biotransformation. 2. Vol. 3. Elsevier; Oxford: 2009. Comprehensive Toxicology. in press.
    1. Vore ME. Efflux transporters. In: Guengerich FP, McQueeen CA Series Ed, editors. Biotransformation. 2. Vol. 3. Elsevier; Oxford: 2009. Comprehensive Toxicology. in press.

Publication types

Substances