doi: 10.1038/351117a0.
Male development of chromosomally female mice transgenic for Sry
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- PMID: 2030730
- DOI: 10.1038/351117a0
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Male development of chromosomally female mice transgenic for Sry
Nature.
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Abstract
The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.
Comment in
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Sex determination. The making of male mice.Nature. 1991 May 9;351(6322):96. doi: 10.1038/351096a0. Nature. 1991. PMID: 2030741 No abstract available.
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