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. 1991 May 9;351(6322):117-21.
doi: 10.1038/351117a0.

Male development of chromosomally female mice transgenic for Sry

P Koopman  1 , J Gubbay, N Vivian, P Goodfellow, R Lovell-Badge
Affiliations

Male development of chromosomally female mice transgenic for Sry

P Koopman et al. Nature. .

Abstract

The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

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