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Review
. 2010 Feb;57(1):83-96.
doi: 10.1016/j.pcl.2009.11.002.

T-cell-based therapies for malignancy and infection in childhood

Nabil Ahmed  1 , Helen E Heslop, Crystal L Mackall
Affiliations
Review

T-cell-based therapies for malignancy and infection in childhood

Nabil Ahmed et al. Pediatr Clin North Am. 2010 Feb.

Abstract

One major advance in T-cell-based immunotherapy in the last 20 years has been the molecular definition of numerous viral and tumor antigens. Adoptive T-cell transfer has shown definite clinical benefit in the prophylaxis and treatment of viral infections that develop in pediatric patients after allogeneic transplant and in posttransplant lymphoproliferative disease associated with the Epstein-Barr virus. Developing adoptive T-cell therapies for other malignancies presents additional challenges. This article describes the recent advances in T-cell-based therapies for malignancy and infection in childhood and strategies to enhance the effector functions of T cells and optimize the cellular product, including gene modification and modulation of the host environment.

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Figures

Figure 1
Figure 1. Generating CTLs by Repeated Ex-vivo stimulation
Low frequency virus specific CTLs in a peripheral blood mononuclear cell population are expanded by primary and secondary stimulation with antigen expressed on antigen presenting cells followed by expansion with IL2. The resulting population is enriched for T cells specific for the viral antigen.
See this image and copyright information in PMC

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