Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 May;46(7):1177-80.
doi: 10.1016/j.ejca.2010.02.039. Epub 2010 Mar 20.

Cancer metastasis as a therapeutic target

Jonathan Sleeman  1 , Patricia S Steeg
Affiliations
Review

Cancer metastasis as a therapeutic target

Jonathan Sleeman et al. Eur J Cancer. 2010 May.

Abstract

Despite many years of basic and clinical research aimed at curbing tumour growth, metastasis remains the prime reason why cancer patients succumb to their disease. Effective translational research is urgently required, yet is not always easy to achieve. Here we review reasons why metastasis as a disease process has proven difficult to control, and suggest ways in which translational research in this area can be strengthened and advanced.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement

None declared.

Similar articles

See all similar articles

Cited by

  • Toward a drug development path that targets metastatic progression in osteosarcoma.
    Khanna C, Fan TM, Gorlick R, Helman LJ, Kleinerman ES, Adamson PC, Houghton PJ, Tap WD, Welch DR, Steeg PS, Merlino G, Sorensen PH, Meltzer P, Kirsch DG, Janeway KA, Weigel B, Randall L, Withrow SJ, Paoloni M, Kaplan R, Teicher BA, Seibel NL, Smith M, Uren A, Patel SR, Trent J, Savage SA, Mirabello L, Reinke D, Barkaukas DA, Krailo M, Bernstein M. Khanna C, et al. Clin Cancer Res. 2014 Aug 15;20(16):4200-9. doi: 10.1158/1078-0432.CCR-13-2574. Epub 2014 May 6. Clin Cancer Res. 2014. PMID: 24803583 Free PMC article.
  • Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.
    Muinonen-Martin AJ, Susanto O, Zhang Q, Smethurst E, Faller WJ, Veltman DM, Kalna G, Lindsay C, Bennett DC, Sansom OJ, Herd R, Jones R, Machesky LM, Wakelam MJ, Knecht DA, Insall RH. Muinonen-Martin AJ, et al. PLoS Biol. 2014 Oct 14;12(10):e1001966. doi: 10.1371/journal.pbio.1001966. eCollection 2014 Oct. PLoS Biol. 2014. PMID: 25313567 Free PMC article.
  • Dormancy in cancer metastasis: keys to moving forward.
    Welch DR. Welch DR. Cancer Metastasis Rev. 2023 Mar;42(1):5-7. doi: 10.1007/s10555-023-10083-5. Cancer Metastasis Rev. 2023. PMID: 36680642 Free PMC article. No abstract available.
  • Osteosarcoma and Metastasis.
    Sheng G, Gao Y, Yang Y, Wu H. Sheng G, et al. Front Oncol. 2021 Dec 10;11:780264. doi: 10.3389/fonc.2021.780264. eCollection 2021. Front Oncol. 2021. PMID: 34956899 Free PMC article. Review.
  • Vimentin Intermediate Filaments as Potential Target for Cancer Treatment.
    Strouhalova K, Přechová M, Gandalovičová A, Brábek J, Gregor M, Rosel D. Strouhalova K, et al. Cancers (Basel). 2020 Jan 11;12(1):184. doi: 10.3390/cancers12010184. Cancers (Basel). 2020. PMID: 31940801 Free PMC article. Review.
See all "Cited by" articles

References

    1. Ferlay J, Autier P, Boniol M, et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18(3):581–92. - PubMed
    1. Sporn MB. The war on cancer. Lancet 1996;347(9012):1377–81. - PubMed
    1. Steeg PS, Theodorescu D. Metastasis: a therapeutic target for cancer. Nat Clin Pract Oncol 2008;5(4):206–19. - PMC - PubMed
    1. Steeg PS. Heterogeneity of drug target expression among metastatic lesions: lessons from a breast cancer autopsy program. Clin Cancer Res 2008;14(12):3643–5. - PMC - PubMed
    1. Suit HD. Local control and patient survival. Int J Radiat Oncol Biol Phys 1992;23(3):653–60. - PubMed

Publication types

MeSH terms