Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 May;54(5):2228-30.
doi: 10.1128/AAC.01572-09. Epub 2010 Mar 22.

Plasmodium vivax susceptibility to ferroquine

M L Leimanis  1 , A Jaidee, K Sriprawat, S Kaewpongsri, R Suwanarusk, M Barends, A P Phyo, B Russell, L Renia, F Nosten
Affiliations

Plasmodium vivax susceptibility to ferroquine

M L Leimanis et al. Antimicrob Agents Chemother. 2010 May.

Abstract

The novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquine-resistant Plasmodium falciparum. The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P. vivax schizont maturation (median 50% inhibitory concentration, 15 nM; n = 42). No significant cross-sensitivity between ferroquine and other antimalarials was detected. This drug may be a suitable replacement for chloroquine in the treatment of drug-resistant P. vivax malaria.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Median ex vivo sensitivities (75% CI) of fresh P. vivax isolates from the Thailand-Myanmar border to FQ, its major metabolite, and a range of standard antimalarials. EC50, 50% effective concentration; ns, not statistically significant.
FIG. 2.
FIG. 2.
Comparative stage-specific effects of CQ and FQ on the schizont maturation of P. vivax and P. falciparum treated at the ring stage versus the trophozoite stage.
See this image and copyright information in PMC

References

    1. Anstey, N. M., B. Russell, T. W. Yeo, and R. N. Price. 2009. The pathophysiology of vivax malaria. Trends Parasitol. 25:220-227. - PubMed
    1. Atteke, C., J. M. Ndong, A. Aubouy, L. Maciejewski, J. Brocard, J. Lebibi, and P. Deloron. 2003. In vitro susceptibility to a new antimalarial organometallic analogue, ferroquine, of Plasmodium falciparum isolates from the Haut-Ogooue region of Gabon. J. Antimicrob. Chemother. 51:1021-1024. - PubMed
    1. Baird, J. K. 2009. Resistance to therapies for infection by Plasmodium vivax. Clin. Microbiol. Rev. 22:508-534. - PMC - PubMed
    1. Barends, M., A. Jaidee, N. Khaohirun, P. Singhasivanon, and F. Nosten. 2007. In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border. Malar. J. 6:81. - PMC - PubMed
    1. Biot, C., L. Delhaes, C. M. N′Diaye, L. A. Maciejewski, D. Camus, D. Dive, and J. S. Brocard. 1999. Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds. Bioorg. Med. Chem. 7:2843-2847. - PubMed

Publication types

MeSH terms

LinkOut - more resources