Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Mar 30;107(13):5699-700.
doi: 10.1073/pnas.1001277107. Epub 2010 Mar 22.

Targeting a kinetochore-associated motor protein to kill cancer cells

Sarah A Wacker  1 , Tarun M Kapoor
Affiliations
Comment

Targeting a kinetochore-associated motor protein to kill cancer cells

Sarah A Wacker et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
GSK923295, an inhibitor of the mitotic kinesin CENP-E. (A) Normal cell division requires alignment of chromosomes at the equator of the bipolar spindle (the metaphase plate). (B) Loss of CENP-E function results in a few chromosomes that remain stuck at spindle poles. (C) Chemical structures of GSK923295, the CENP-E inhibitor, and monastrol, the kinesin-5 inhibitor. These inhibitors bind at an allosteric site (yellow), which is ∼10 Å from the ADP-binding site (red), in the kinesin ATPase domain, as depicted on the CENP-E motor domain (PDB: 1T5C) (D).
See this image and copyright information in PMC

Comment on

  • Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.
    Wood KW, Lad L, Luo L, Qian X, Knight SD, Nevins N, Brejc K, Sutton D, Gilmartin AG, Chua PR, Desai R, Schauer SP, McNulty DE, Annan RS, Belmont LD, Garcia C, Lee Y, Diamond MA, Faucette LF, Giardiniere M, Zhang S, Sun CM, Vidal JD, Lichtsteiner S, Cornwell WD, Greshock JD, Wooster RF, Finer JT, Copeland RA, Huang PS, Morgans DJ Jr, Dhanak D, Bergnes G, Sakowicz R, Jackson JR. Wood KW, et al. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5839-44. doi: 10.1073/pnas.0915068107. Epub 2010 Feb 18. Proc Natl Acad Sci U S A. 2010. PMID: 20167803 Free PMC article.

References

    1. Wood KW, et al. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E (CENP-E) Proc Natl Acad Sci USA. 2010;107:5839–5844. - PMC - PubMed
    1. Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004;4:253–265. - PubMed
    1. Rieder CL, Maiato H. Stuck in division or passing through: What happens when cells cannot satisfy the spindle assembly checkpoint. Dev Cell. 2004;7:637–651. - PubMed
    1. Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999;286:971–974. - PubMed
    1. Miki H, Okada Y, Hirokawa N. Analysis of the kinesin superfamily: Insights into structure and function. Trends Cell Biol. 2005;15:467–476. - PubMed

MeSH terms

LinkOut - more resources