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. 2010;19(4):1149-53.
doi: 10.3233/JAD-2010-1319.

Statin users without an APOE-epsilon4 allele have increased insulin resistance

Brian T VanFossen  1 , G Stennis Watson, Laura D Baker, Kristoffer W Rhoads, Brenna A Cholerton, Mark A Reger, Stephen R Plymate, Gerald Schellenberg, Suzanne Craft
Affiliations

Statin users without an APOE-epsilon4 allele have increased insulin resistance

Brian T VanFossen et al. J Alzheimers Dis. 2010.

Abstract

The present study examined the relationships among statin use, APOE genotype, and insulin resistance as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) in healthy older adults. APOE epsilon4- (i.e., not having an epsilon4 allele) statin users had higher HOMA-IR values compared with epsilon4+/statin users (p=0.0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele.

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Figures

Figure 1
Figure 1
Insulin resistance, statin use, and APOE genotype. HOMA-IR values were significantly higher (indicating more insulin resistance) (1A) for statin users than non-users, p = 0.0478, and (1B) non-narriers of an APOE ε4 allele (ε4-) than APOE ε4 carriers (ε4-), p = 0.0188. (1C).Statin use moderated the relationship between APOE genotype and fasting insulin levels, p = 0.0473, and (1D) exploratory analyses suggested an allele-dose effect, which did not to reach significance.
Figure 1
Figure 1
Insulin resistance, statin use, and APOE genotype. HOMA-IR values were significantly higher (indicating more insulin resistance) (1A) for statin users than non-users, p = 0.0478, and (1B) non-narriers of an APOE ε4 allele (ε4-) than APOE ε4 carriers (ε4-), p = 0.0188. (1C).Statin use moderated the relationship between APOE genotype and fasting insulin levels, p = 0.0473, and (1D) exploratory analyses suggested an allele-dose effect, which did not to reach significance.
Figure 1
Figure 1
Insulin resistance, statin use, and APOE genotype. HOMA-IR values were significantly higher (indicating more insulin resistance) (1A) for statin users than non-users, p = 0.0478, and (1B) non-narriers of an APOE ε4 allele (ε4-) than APOE ε4 carriers (ε4-), p = 0.0188. (1C).Statin use moderated the relationship between APOE genotype and fasting insulin levels, p = 0.0473, and (1D) exploratory analyses suggested an allele-dose effect, which did not to reach significance.
Figure 1
Figure 1
Insulin resistance, statin use, and APOE genotype. HOMA-IR values were significantly higher (indicating more insulin resistance) (1A) for statin users than non-users, p = 0.0478, and (1B) non-narriers of an APOE ε4 allele (ε4-) than APOE ε4 carriers (ε4-), p = 0.0188. (1C).Statin use moderated the relationship between APOE genotype and fasting insulin levels, p = 0.0473, and (1D) exploratory analyses suggested an allele-dose effect, which did not to reach significance.
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References

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