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. 1991 May;51(5):1000-4.
doi: 10.1097/00007890-199105000-00013.

Effect of cold ischemia time on the early outcome of human hepatic allografts preserved with UW solution

H Furukawa  1 , S Todo, O Imventarza, A Casavilla, Y M Wu, C Scotti-Foglieni, B Broznick, J Bryant, R Day, T E Starzl
Affiliations

Effect of cold ischemia time on the early outcome of human hepatic allografts preserved with UW solution

H Furukawa et al. Transplantation. 1991 May.

Abstract

Five hundred ninety-three cadaveric livers were used for primary liver transplantation between October 24, 1987, and May 19, 1989. The grafts were procured with a combined method, using in situ cooling with cold electrolyte solution and backtable flushing with UW solution. The mean cold-ischemia time was 12.8 (range 2.4-34.7) hr. The cases were divided into 5 groups according to the cold-ischemia time: group 1: less than 10 hr (n = 223); group 2: 10-14 hr (n = 188); group 3: 15-19 hr (n = 101); group 4: 20-24 hr (n = 52); and group 5: greater than or equal to 25 hr (n = 29). There was no difference between the 5 groups in 1-year patient survival, highest SGOT in first week after operation, and SGOT and total bilirubin during the first month after operation. However, with a logistic regression model, the retransplantation rate (P = 0.001) and primary nonfunction rate (P = 0.006) significantly rose as cold-ischemia time increased, meaning that the equivalency of patient survival was increasingly dependent on aggressive retransplantation.

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Figures

Figure 1
Figure 1
Distribution of cold-ischemia time (CIT).
Figure 2
Figure 2
Recipient patient survival according to CIT. Actual follow-up for all cases was more than 1 year.
Figure 3
Figure 3
Graft survival according to CIT. Note the significantly increased early loss rate of grafts with the longer ischemia times.
Figure 4
Figure 4
Incidence and cause of retransplantation within 2 weeks.
Figure 5
Figure 5
Estimated rates of retransplantation and primary nonfunction of grafts related correlated with cold-ischemia time (CIT), using a logistic regression model.
Figure 6
Figure 6
SGOT during the first month related to CIT. See text for explanation of possible culling artifact.
Figure 7
Figure 7
Total bilirubin in different CIT groups during the first month. See text for explanation of possible culling artifact.
Figure 8
Figure 8
Highest SGOT values during the first 7 days after transplantation of all 593 grafts and the relation of these figures to CIT. There was no correlation.
See this image and copyright information in PMC

References

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