Review
Cellular action of gastrointestinal polypeptide hormones
- PMID: 203165
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Review
Cellular action of gastrointestinal polypeptide hormones
Acta Physiol Acad Sci Hung.
1976.
Abstract
The present state of chemistry, structure-activity relationship and cellular mode of action of gastrointestinal polypeptide hormones (gastrin, secretin, cholecystokinin-pancreozymin, caerulein and bombesin) are reviewed. Possible structure of polypeptide receptors and the mechanism of peptide--receptor interaction are described, and the role of acetylcholine and histamine in secretion discussed. The present data support the hormonal-receptor significance of cyclic nucleotides (cAMP, cGMP) in the cellular regulation of secretion.
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