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Case Reports
. 1991 Mar;5(2):232-4.
doi: 10.1007/BF01095961.

Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney

K Yoshioka  1 , T Takemura, M Kanasaki, N Akano, S Maki
Affiliations
Case Reports

Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney

K Yoshioka et al. Pediatr Nephrol. 1991 Mar.

Abstract

Infiltrating cells were analysed in renal biopsy tissue obtained from a 15-year-old girl with acute interstitial nephritis and uveitis using monoclonal antibodies specific for mononuclear cell surface markers. The interstitial infiltrates consisted mainly of T cells and monocytes/macrophages. A considerable proportion of the infiltrating cells were identified by a monoclonal antibody against the interleukin-2 receptor, indicating that a majority of those immune cells are activated. This observation documents the participation of cell-mediated immune injury in interstitial nephritis associated with uveitis.

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References

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