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. 1991 Jun 1;51(11):3059-61.

Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites

G J Powell  1 , J Southby, J A Danks, R G Stillwell, J A Hayman, M A Henderson, R C Bennett, T J Martin
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  • PMID: 2032246

Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites

G J Powell et al. Cancer Res. .

Abstract

Parathyroid hormone-related protein (PTHrP) has recently been identified in 60% of a series of primary breast cancers. The detection of a bone-resorbing factor in tumors with a propensity to metastasize to bone prompted study of PTHrP in breast cancer metastasis. PTHrP was localized by immunohistology in 12 of 13 (92%) breast cancer metastases in bone and in 3 of 18 (17%) metastases in non-bone sites. The statistical difference was highly significant (P less than 0.0001). Production of PTHrP as a bone-resorbing agent may contribute to the ability of breast cancers to grow as bone metastases.

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