The beta-adrenergic activity of some monosubstituted phenethanolamines
- PMID: 203235
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The beta-adrenergic activity of some monosubstituted phenethanolamines
Arch Int Pharmacodyn Ther.
1977 Nov.
Abstract
A series of monosubstituted phenethanolamines with N-isopropyl and N-tert-butyl substituents has been prepared. A detailed pharmacological study has been made of the beta-adrenergic activity of these materials as the nitrogen substituent and the nature and position of the phenyl substituent were changed, and their selectivity has been determined for beta1- and beta2-adrenoceptors in guinea-pig and cat tissues.
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