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. 2010;15(4):405-15.
doi: 10.1634/theoncologist.2009-0295. Epub 2010 Mar 23.

Prognostic factors and morbidities after completion surgery in patients undergoing initial chemoradiation therapy for locally advanced cervical cancer

Cyril Touboul  1 , Catherine Uzan, Audrey Mauguen, Sebastien Gouy, Annie Rey, Patricia Pautier, Catherine Lhommé, Pierre Duvillard, Christine Haie-Meder, Philippe Morice
Affiliations

Prognostic factors and morbidities after completion surgery in patients undergoing initial chemoradiation therapy for locally advanced cervical cancer

Cyril Touboul et al. Oncologist. 2010.

Abstract

Purpose: The aim of this study was to evaluate the prognostic factors and morbidities of patients undergoing completion surgery for locally advanced-stage cervical cancer after initial chemoradiation therapy (CRT).

Patients and methods: Patients fulfilling the following inclusion criteria were studied: stage IB2-IVA cervical carcinoma, tumor initially confined to the pelvic cavity on conventional imaging, pelvic external radiation therapy with delivery of 45 Gy to the pelvic cavity and concomitant chemotherapy (cisplatin, 40 mg/m(2) per week) followed by uterovaginal brachytherapy, and completion surgery after the end of radiation therapy including at least a hysterectomy.

Results: One-hundred fifty patients treated in 1998-2007 fulfilled the inclusion criteria. Prognostic factors for overall survival in the multivariate analysis were the presence and level of nodal spread (positive pelvic nodes alone: hazard ratio [HR], 2.03; positive para-aortic nodes: HR, 5.46; p < .001) and the presence and size of residual disease (RD) in the cervix (p = .02). Thirty-seven (25%) patients had 55 postoperative complications. The risk for complications was higher with a radical hysterectomy (p = .04) and the presence of cervical RD (p = .01).

Conclusion: In this series, the presence and size of RD and histologic nodal involvement were the strongest prognostic factors. Such results suggest that the survival of patients treated using CRT for locally advanced cervical cancer could potentially be enhanced by improving the rate of complete response in the irradiated area (cervix or pelvic nodes) and by initially detecting patients with para-aortic spread so that treatment could be adapted in such patients. The morbidity of completion surgery is high in this context.

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Conflict of interest statement

Disclosures

Cyril Touboul: None; Catherine Uzan; None; Audrey Mauguen: None; Sebastien Gouy: None; Annie Rey: None; Patricia Pautier: None; Catherine Lhommé: None; Pierre Duvillard: None; Christine Haie-Meder: None; Philippe Morice: None.

Section editors Peter G. Harper and Dennis S. Chi have disclosed no financial relationships relevant to the content of this article.

The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias.

Figures

Figure 1.
Figure 1.
Overall survival according to the size of residual disease (RD) on the hysterectomy specimen.
See this image and copyright information in PMC

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