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. 2010 Mar-Apr;51(2):157-65.
doi: 10.1176/appi.psy.51.2.157.

Psychological determinants of health-related quality of life in patients with chronic liver disease

Jolie J Gutteling  1 , Hugo J Duivenvoorden, Jan J V Busschbach, Robert A de Man, Anne-Sophie E Darlington
Affiliations

Psychological determinants of health-related quality of life in patients with chronic liver disease

Jolie J Gutteling et al. Psychosomatics. 2010 Mar-Apr.

Abstract

Background: The negative impact of chronic liver disease on health-related quality of life (HRQoL) of patients with chronic liver disease (CLD) has long been established, and treatable physiological or psychological factors may potentially influence HRQoL.

Objective: The authors assessed the interrelationships of multiple psychological factors and HRQoL in patients with CLD.

Method: Both direct and indirect relationships among HRQoL, depression, anxiety, coping, and self-efficacy in 164 patients with CLD were assessed.

Results: Depression, largely determined by low self-efficacy and, possibly, by use of maladaptive coping strategies, influenced HRQoL in three groups of liver patients.

Conclusion: HRQoL in CLD patients may be positively affected by enhancing coping and self-efficacy skills, thus improving levels of depression.

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