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Review
. 2010 Apr;3(4):410-5.
doi: 10.1158/1940-6207.CAPR-10-0040. Epub 2010 Mar 23.

Vaccine prevention of cancer: can endogenous antigens be targeted?

Louis M Weiner  1 , Rishi Surana, Joseph Murray
Affiliations
Review

Vaccine prevention of cancer: can endogenous antigens be targeted?

Louis M Weiner et al. Cancer Prev Res (Phila). 2010 Apr.

Abstract

This perspective on the report by Beatty et al. in this issue of the journal (beginning on page 438) discusses the prevention of cancer through vaccination strategies that target antigens associated with tumor promotion and progression. Such approaches were first developed for treating cancer. We address cancer vaccination in the context of a mouse model of inflammatory bowel disease expressing MUC1, an epithelial mucin aberrantly expressed during chronic inflammation and in colorectal carcinogenesis, and in a broader context that includes the potential of targeting the tumor microenvironment for immunoprevention in humans. Obstacles in developing effective cancer vaccines, including antigen selection, immunoediting, and tumor-mediated immunosuppression, are also discussed.

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References

    1. Beatty PL, Narayanan S, Gariépy J, Ranganathan S, Finn OJ. Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis associated colon cancer. Cancer Prev Res. 2010;3:XX. Ed: Please complete once issue is paginated. - PMC - PubMed
    1. WHO vaccine-preventable diseases: monitoring system – 2008 global summary. Expanded Programme on Immunization of the Department of Immunization, Vaccines and Biologicals, World Health Organization; Geneza, Switzerland: Dec, 2008. 2008.
    1. Haigh PI, Difronzo LA, Gammon G, Morton DL. Vaccine therapy for patients with melanoma. Oncology (Williston Park) 1999;13:1561–74. discussion 74 passim. - PubMed
    1. Shumway NM, Ibrahim N, Ponniah S, Peoples GE, Murray JL. Therapeutic breast cancer vaccines: a new strategy for early-stage disease. BioDrugs. 2009;23:277–87. - PubMed
    1. Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology. 2004;127:S35–50. - PubMed