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Review
. 2010 Apr;3(4):420-3.
doi: 10.1158/1940-6207.CAPR-10-0052. Epub 2010 Mar 23.

Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection

Brigitte N Gomperts  1 , Avrum Spira, David E Elashoff, Steven M Dubinett
Affiliations
Review

Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection

Brigitte N Gomperts et al. Cancer Prev Res (Phila). 2010 Apr.

Abstract

This perspective on Varella-Garcia et al. (beginning on p. 447 in this issue of the journal) discusses the role of sputum-based biomarkers in the risk assessment and early detection of lung cancer. The importance of the detection of sputum epithelial chromosomal aneusomy by fluorescence in situ hybridization (FISH) as a potential risk or early-detection biomarker is discussed in the context of other biomarkers and models in lung carcinogenesis. The presently reported findings on FISH in sputum cells are an important contribution worthy of further investigation in defined clinical settings.

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