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. 2010 Feb;30(2):653-60.

Predictors of survival in stage IV metastatic colorectal cancer

Michalis Zacharakis  1 , Ioannis D Xynos, Andreas Lazaris, Tsaousi Smaro, Christos Kosmas, Anna Dokou, Evangelos Felekouras, Efstathios Antoniou, Aris Polyzos, John Sarantonis, John Syrios, George Zografos, Alexandros Papalambros, Nikolas Tsavaris
Affiliations
  • PMID: 20332485

Predictors of survival in stage IV metastatic colorectal cancer

Michalis Zacharakis et al. Anticancer Res. 2010 Feb.

Abstract

The aim of this study was to evaluate predictors of survival in stage IV metastatic colorectal cancer (CRC).

Patients and methods: A total of 541 patients with histologically proven metastatic CRC (UICC stage IV) were retrospectively analysed and 37 variables were tested for their potential relationship to survival.

Results: Mean survival time was recorded at 12.8 months [95% confidence interval (CI) 12.0-13.5]. Three factors were independently associated with improved survival: combination chemotherapy, improved performance status and dermatological complications. Eight factors were independently associated with unfavorable survival: worsened performance status, C-reactive protein >5 mg/dl, anemia, anorexia, weight loss > or =10%, fatigue, hypoalbuminemia and blood transfusions.

Conclusion: A number of factors could be used as predictors of survival in patients with stage IV metastatic CRC. Patients who are relatively fit, have low CRP levels and tolerate combination chemotherapy appear to have a more favorable survival outcome.

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