Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jun 1;50(7):666-670.
doi: 10.1002/jlcr.1381.

The synthesis of deuterium-labeled spermine, N-acetylspermine and N-acetylspermidine

Vijay Gawandi  1 , Paul F Fitzpatrick
Affiliations

The synthesis of deuterium-labeled spermine, N-acetylspermine and N-acetylspermidine

Vijay Gawandi et al. J Labelled Comp Radiopharm. .

Abstract

The synthesis of deuterium labeled spermine, N(1)-acetylspermine and N(1)-acetylspermidine is reported. 1,1,3,3-(2)H(4)-N(1)-Acetylspermine hydrochloride, 1,1,3,3-(2)H(4)-N(1)-acetylspermidine hydrochloride and 1,1,3,3,10,10,12,12-(2)H(8)-spermine dihydrochloride were obtained in seven, four and three steps respectively. All the syntheses were carried out by simple protection and deprotection steps from commonly used selective protecting reagents. These deuterium labeled compounds can be used as mechanistic probes of polyamine oxidizing enzymes.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Scheme 1
Scheme 1
Scheme 2
Scheme 2
Scheme 3
Scheme 3
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Tabor CW, Tabor H. Microbiol. Rev. 1985;49:81–99. - PMC - PubMed
    1. Pegg AE. Biochem. J. 1986;234:249–262. - PMC - PubMed
    1. Heby O. Differentiation. 1981;19:1–20. - PubMed
    1. Tabor CW, Tabor H. Annu. Rev. Biochem. 1984;53:749–790. - PubMed
    1. Wallace HM, Fraser AV, Hughes A. Biochem. J. 2003;376:1–14. - PMC - PubMed

LinkOut - more resources