Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2010 May;51(5):667-9.
doi: 10.1007/s00108-009-2545-1.

[Withdrawal in a patient with an implantable drug delivery system in spite of continuation of opiate therapy]

[Article in German]
S Lochner  1 , U Heinrich-Gräfe, W Kirch
Affiliations
Case Reports

[Withdrawal in a patient with an implantable drug delivery system in spite of continuation of opiate therapy]

[Article in German]
S Lochner et al. Internist (Berl). 2010 May.

Abstract

A male patient with severe chronic pain has been treated with a combined drug therapy scheme of morphine and clonidine. After cessation of clonidine the patient reported opiate-withdrawal symptoms with agitation, polyuria, diarrhea, and hyperalgesia. It is known that the combination of these two substances causes synergistic analgetic effects. The abrupt cessation of clonidine after a combined administration with morphine seems to lead to a relative decrease in opiate effects and furthermore excite opiate-withdrawal symptoms.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Stereotact Funct Neurosurg. 2000;75(4):167-75 - PubMed
    1. Schmerz. 2007 Feb;21(1):15-8, 20-4, 26-7 - PubMed
    1. Pharm Unserer Zeit. 1983 Jul;12(4):119-22 - PubMed
    1. Brain Res. 1987 Mar 3;405(1):84-93 - PubMed
    1. Lancet. 1978 Sep 16;2(8090):599-602 - PubMed

LinkOut - more resources