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Case Reports
. 2010 May;51(5):667-9.
doi: 10.1007/s00108-009-2545-1.

[Withdrawal in a patient with an implantable drug delivery system in spite of continuation of opiate therapy]

[Article in German]
S Lochner  1 , U Heinrich-Gräfe, W Kirch
Affiliations
Case Reports

[Withdrawal in a patient with an implantable drug delivery system in spite of continuation of opiate therapy]

[Article in German]
S Lochner et al. Internist (Berl). 2010 May.

Abstract

A male patient with severe chronic pain has been treated with a combined drug therapy scheme of morphine and clonidine. After cessation of clonidine the patient reported opiate-withdrawal symptoms with agitation, polyuria, diarrhea, and hyperalgesia. It is known that the combination of these two substances causes synergistic analgetic effects. The abrupt cessation of clonidine after a combined administration with morphine seems to lead to a relative decrease in opiate effects and furthermore excite opiate-withdrawal symptoms.

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References

    1. Stereotact Funct Neurosurg. 2000;75(4):167-75 - PubMed
    1. Schmerz. 2007 Feb;21(1):15-8, 20-4, 26-7 - PubMed
    1. Pharm Unserer Zeit. 1983 Jul;12(4):119-22 - PubMed
    1. Brain Res. 1987 Mar 3;405(1):84-93 - PubMed
    1. Lancet. 1978 Sep 16;2(8090):599-602 - PubMed

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