Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Dec;23(12):1377-83.
doi: 10.3109/14767051003710284. Epub 2010 Mar 24.

The Normal anticoagulant system and risk of placental abruption: protein C, protein S and resistance to activated protein C

Cande V Ananth  1 , Carl A Nath, Claire Philipp; New Jersey Placental Abruption Study
Collaborators, Affiliations

The Normal anticoagulant system and risk of placental abruption: protein C, protein S and resistance to activated protein C

Cande V Ananth et al. J Matern Fetal Neonatal Med. 2010 Dec.

Abstract

Objective: To examine the association between maternal thrombophilia associated with anticoagulation (proteins C and S and activated protein C resistance ratio, APCR) and risk of placental abruption.

Methods: Data were derived from a case-control study - The New Jersey-Placental Abruption Study (2002-2007). Maternal blood was collected from abruption cases and controls and was assayed for the thrombophilias. Decreased protein C, S and APCR was defined as values <5% and <10% among controls.

Results: Of a total of 132 cases and 127 controls, 3 were heterozygous for the factor V Leiden mutation (1 case and 2 controls). Mean (± standard deviation) protein C (114.2 ± 25.6 vs. 121.4 ± 27.6; P=0.009), protein S (39.9 ± 18.4 vs. 35.7 ± 15.2; P=0.043) and APCR (2.86 ± 0.29 vs. 2.88 ± 0.27; P=0.039) were different between cases and controls. Abruption cases were associated with an odds ratio of 3.2 (95% CI 1.2, 9.9) in relation to decreased protein C (<Fifth centile). Decreases in both protein S and APCR ratio were not associated with abruption.

Conclusions: A decrease in protein C was associated with an increased risk for abruption, suggesting an important role for the physiologic anticoagulant system in the etiology of placental abruption.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Distributions (mean and standard deviation) of protein Cactivity (%), protein S activity (%), and activated protein C resistance ratio between placental abruption cases and controls. Unadjusted difference (95% confidence interval) between cases and controls for each anticoagulantassay are also shown
See this image and copyright information in PMC

References

    1. Paidas MJ, Ku DH, Arkel YS. Screening and management of inherited thrombophilias in the setting of adverse pregnancy outcome. Clin Perinatol. 2004;31(4):783–805. vii. - PubMed
    1. Greer IA. Thrombophilia: implications for pregnancy outcome. Thromb Res. 2003;109(2–3):73–81. - PubMed
    1. Comp PC, Thurnau GR, Welsh J, Esmon CT. Functional and immunologic protein S levels are decreased during pregnancy. Blood. 1986;68(4):881–5. - PubMed
    1. Cumming AM, Tait RC, Fildes S, Yoong A, Keeney S, Hay CR. Development of resistance to activated protein C during pregnancy. Br J Haematol. 1995;90(3):725–7. - PubMed
    1. Greer IA. Epidemiology, risk factors and prophylaxis of venous thrombo-embolism in obstetrics and gynaecology. Baillieres Clin Obstet Gynaecol. 1997;11(3):403–30. - PubMed

Publication types

LinkOut - more resources