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. 2010 Mar 10;15(3):1578-89.
doi: 10.3390/molecules15031578.

Synthesis, spectral and thermal studies of new rutin vanadyl complexes

Valentina Uivarosi  1 , Stefania Felicia Barbuceanu, Victoria Aldea, Corina-Cristina Arama, Mihaela Badea, Rodica Olar, Dana Marinescu
Affiliations

Synthesis, spectral and thermal studies of new rutin vanadyl complexes

Valentina Uivarosi et al. Molecules. .

Abstract

Complexes between oxovanadium (IV) cation and flavonoid derivatives were developed recently in order to increase the intestinal absorption and to reduce the toxicity of vanadium compounds. For these reasons, is interesting to investigate the complexation process between flavonoid rutin (Rut) and vanadyl cation in order to isolate new complexes. Two new complexes [VO(Rut)(H2O)2](SO4)0.5 x 2 H2O and [VO(Rut)2] x 4 H2O have been obtained and characterized by elemental and thermal analyses and several spectroscopic techniques (ESI-MS, IR, UV-Vis, fluorescence). The studies concerning complex formation between vanadyl and rutin (Rut) performed in different solutions show the formation of mononuclear complexes with 1:1 and 1:2 metal to ligand stoichiometry.

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Figures

Figure 1
Figure 1
(a) Base structure of flavonoids. (b) Structure of rutin, a flavonol derivative.
Figure 2
Figure 2
Mass spectrum of [VO(rutin)(H2O)2](SO4)0.5 2H2O.
Figure 3
Figure 3
Diffuse reflectance electronic spectra of (a) [VO(rutin)(H2O)2](SO4)0.5 2H2O and (b) [VO(Rut)2] 4H2O.
Figure 4
Figure 4
Fluorescence spectra of (a) rutin trihydrate, (b) [VO(rutin)(H2O)2](SO4)0.5 2H2O and (c) [VO(Rut)2] 4H2O (λex = 260 nm, λem = 302 nm).
Figure 5
Figure 5
TG and DTA curves of [VO(rutin)(H2O)2](SO4)0.5 2H2O.
Figure 6
Figure 6
The proposed coordination for [VO(Rut)(H2O)2]+ (1) and [VO(Rut)2] (2).
Figure 7
Figure 7
Plot of the VO2+-rutin complex formation in a CH3OH-H2O (70:30) mixture; (a) CVO2+ + C rutin = 0.10 mM. (b) CVO2+ + C rutin = 0.05 mM.
Figure 8
Figure 8
Absorbance versus rutin concentration (C vanadyl sulfate = 0.05 mM).
Figure 9
Figure 9
Plot of the VO2+-rutin complex formation in aqueous solution (pH 6); CVO2+ + Crutin = 0.10 mM.
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