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. 1991 Jun;65(6):3349-53.
doi: 10.1128/JVI.65.6.3349-3353.1991.

Transgenic thymocytes are refractory to transformation by the human T-cell leukemia virus type I tax gene

M I Nerenberg  1 , T Minor, J Price, D N Ernst, T Shinohara, H Schwarz
Affiliations

Transgenic thymocytes are refractory to transformation by the human T-cell leukemia virus type I tax gene

M I Nerenberg et al. J Virol. 1991 Jun.

Abstract

Previous transgenic work demonstrated transforming activity of the human T-cell leukemia virus type I Tax protein in fibroblasts. In the present study, a Thy-1-based vector was used to express Tax in thymocytes. These mice developed no functional or neoplastic abnormalities of T cells but developed fibroblastic tumors with a longer latency than in the previous model.

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