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. 2010 Apr 15;20(8):2564-5.
doi: 10.1016/j.bmcl.2010.02.087. Epub 2010 Mar 1.

The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands

Lidiya Stavitskaya  1 , Michael J Seminerio, Marilyn M Matthews-Tsourounis, Rae R Matsumoto, Andrew Coop
Affiliations

The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands

Lidiya Stavitskaya et al. Bioorg Med Chem Lett. .

Abstract

A series of pyridylpiperazines was synthesized and analyzed for sigma receptor binding affinity to determine the optimal pyridyl nitrogen position and chain length for the sigma(1) and sigma(2) receptor recognition. The (3-pyridyl)piperazines and (4-pyridyl)piperazines favor sigma(1) receptors, while previously studied (2-pyridyl)piperazines favor sigma(2) receptors.

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Figure 1
Phenylalkylpiperazinepyridines *Reported in reference ref.
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