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. 2010 Jan-Feb;76(1):107-12.
doi: 10.1590/S1808-86942010000100018.

Maternal and paternal age, birth order and interpregnancy interval evaluation for cleft lip-palate

Daniella Reis Barbosa Martelli  1 , Kaliany Wanessa da Cruz, Letízia Monteiro de Barros, Marise Fernandes Silveira, Mário Sérgio Oliveira Swerts, Hercílio Martelli Júnior
Affiliations

Maternal and paternal age, birth order and interpregnancy interval evaluation for cleft lip-palate

Daniella Reis Barbosa Martelli et al. Braz J Otorhinolaryngol. 2010 Jan-Feb.

Abstract

Cleft lip and palate (CL/P) are the most common congenital craniofacial anomalies.

Aim: To evaluate environmental risk factors for non-syndromic CL/P in a reference care center in Minas Gerais.

Materials and methods: we carried out a case-controlled study, assessing 100 children with clefts and 100 children without clinical alterations. The analysis dimensions (age, skin color, gender, fissure classification, maternal and paternal age, birth order and interpregnancy interval), obtained from a questionnaire; and later we build a data base and the analyses were carried out by the SPSS 17.0 software. The results were analyzed with the relative risk for each variable, in order to estimate the odds ratio with a 95% confidence interval, followed by a bivariate and multivariate analysis.

Results: among 200 children, 54% were males and 46% were females. As far as skin color is concerned most were brown, white and black, respectively. Cleft palates were the most common fissures found (54%), followed by lip cleft (30%) and palate cleft (16%).

Conclusion: although with a limited sample, we noticed an association between maternal age and an increased risk for cleft lip and palate; however, paternal age, pregnancy order and interpregnancy interval were not significant.

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Uncited Reference

    1. Martelli-Junior H, Porto LCVP, Barbosa DRB, Bonan PRF, Freitas AB, Coletta RD. Prevalence of nonsyndromic oral clefts in a reference hospital in Minas Gerais State, between 2000-2005. Braz Oral Res. 2007;21(4):314–317. - PubMed