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Case Reports
. 2010 May 1;50(9):1252-5.
doi: 10.1086/651605.

Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts

Matthew J Memoli  1 , Rachel J Hrabal, Arash Hassantoufighi, Maryna C Eichelberger, Jeffery K Taubenberger
Affiliations
Case Reports

Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts

Matthew J Memoli et al. Clin Infect Dis. .

Abstract

Pandemic 2009 H1N1 virus isolates containing the neuraminidase inhibitor resistance mutation H275Y have been reported. We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir.

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References

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