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. 2010 Jun;39(3):170-6.
doi: 10.1111/j.1600-0684.2010.00409.x. Epub 2010 Mar 15.

Ovarian pathology in rhesus macaques: a 12-year retrospective

A K Marr-Belvin  1 , C C Bailey, H L Knight, S A Klumpp, S V Westmoreland, A D Miller
Affiliations

Ovarian pathology in rhesus macaques: a 12-year retrospective

A K Marr-Belvin et al. J Med Primatol. 2010 Jun.

Abstract

Background: Ovarian pathology is an important cause of decreased fertility and reproductive capability and may impact multiple systems, particularly in aging rhesus macaques.

Methods: Retrospective histopathologic and immunohistochemical analysis of 458 female rhesus macaque necropsies over 12 years at the New England Primate Research Center in Southborough, MA.

Results: Degenerative and inflammatory changes in the ovaries included mineralization, infiltration by lymphocytes, macrophages and multinucleated giant cells, endometriosis, and arteriopathy. Cystic changes included follicular cysts, cystic rete, and mesonephric duct cysts with cystic rete the most common. Neoplasms included granulosa cell tumors, cystadenoma, cystadenocarcinoma, and teratoma.

Conclusions: Ovarian lesions of the rhesus macaque are similar to those of cynomolgus macaques and humans. These lesions are frequently incidental findings but may impact metabolic and neurocognitive studies.

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References

    1. Allan JWE, Buck D. Mechanism of SIV-induced viral fusion involves activation of the viral membrane via CD4; Int Conf AIDS 6:97 (abstract no. S.A.95); 1990.
    1. Amin HK. Ovarian serous neoplasms in the Rhesus monkey. Electron microscopical observations. J Comp Path. 1974;84:161–167. - PubMed
    1. Cline J, Wood CE, Vidal JD, Tarara RP, Buse E, Weinbauer GF, DeRijk, EPCT, VanEsch E. Selected Background Findings and Interpretation of Common Lesions in the Female Reproductive System in Macaques. Toxicologic Pathology. 2008;36:142S–163S. - PMC - PubMed
    1. Crews LM, Kerber WT, Feinman H. An ovarian tumor of dual nature in a rhesus monkey. Pathol Vet. 1967;4:157–161. - PubMed
    1. Crum CP. The Female Genital Tract, Ovarian Tumors in Robbins and Cotran Pathologic Basis of Disease. Philadelphia: Elsevier Saunders; 2005.

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