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. 2010 Mar 26:5:19.
doi: 10.1186/1746-1596-5-19.

Expression and prognostic significance of Cox-2 and p-53 in Hodgkin lymphomas: a retrospective study

Nagehan O Barisik  1 , Suheyla Bozkurt, Mahmut Gumus, Isik Kaygusuz, Nimet Karadayi, Emine Bas, Mahmut Bayik, Tulay Tecimer
Affiliations

Expression and prognostic significance of Cox-2 and p-53 in Hodgkin lymphomas: a retrospective study

Nagehan O Barisik et al. Diagn Pathol. .

Abstract

Background: Cyclooxygenase (cox) is the rate-limiting enzyme, which catalyzes the conversion of arachidonic acid into prostaglandins and contributes to the inflammatory process. Cyclooxygenase-2 (cox-2), which is one of the two isoforms, plays a role in tumor progression and carcinogenesis. p53 contributes to apoptosis, DNA renewal and cell cycle. Studies concerning the relationship of cox-2 and p53 expressions and carcinogenesis are available, but the association between cox-2 and p53 in Hodgkin lymphoma (HL) is not exactly known.In our study, we examined the association of cox-2 and p53 expression, with age, stage, histopathological subtype, and survival in HL. We also examined correlation between cox-2 and p53 expression.

Methods: Cox-2 and p53 expressions in Hodgkin-Reed Sternberg cells (HRS) were examined in 54 patients with HL depending on cox-2 expression, stained cases were classified as positive, and unstained cases as negative. Nuclear staining of HRS cells with p53 was evaluated as positive. The classifications of positivity were as follows: negative if<10%; (1+) if 10-25%; (2+) if 25-50%; (3+) if 50-75%, (4+) if >75%.

Results: Cox-2 and p53 expressions were found in 49 (80%) and 29 (46%) patients, respectively. There were differences between histological subtypes according to cox-2 expression (p = 0.012). Mixed cellular (MC) and nodular sclerosing (NS) subtypes were seen most of the patients and cox-2 expression was evaluated mostly in the mixed cellular subtype.There were no statistically significant relationships between p53 and the histopathological subtypes; or between p53, cox-2 and the factors including stage, age and survival; or between p53 and cox-2 expression (p > 0.05).

Conclusion: Considering the significant relationship between the cox-2 expression and the subtypes of HL, cox-2 expression is higher in MC and NS subtypes. However the difference between these two subtypes was not significant. This submission must be advocated by studies with large series.

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Figures

Figure 1
Figure 1
(cox-2 × 100) cox-2 exspresion in H/R-S cells.
Figure 2
Figure 2
(p53 × 100) p53 expression in H/R-S cells.
Figure 3
Figure 3
Association between Cox-2 expression and survival.
See this image and copyright information in PMC

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