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. 2010 Jun;20(6):421-5.
doi: 10.1016/j.euroneuro.2010.02.011. Epub 2010 Mar 25.

The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats

Martin Weber  1 , Wei-Li Chang, Michelle R Breier, Alex Yang, Mark J Millan, Neal R Swerdlow
Affiliations

The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats

Martin Weber et al. Eur Neuropsychopharmacol. 2010 Jun.

Abstract

Dopamine agonists reduce prepulse inhibition (PPI) of startle in rats. While it is used to predict antipsychotic efficacy, the specific receptor subtypes mediating this effect of dopamine agonists remain unclear. We characterized the effects of sumanirole, a highly selective D2 agonist, on PPI in rats. Sumanirole decreased PPI at 60-120 ms prepulse intervals, and increased PPI at 10-20 ms intervals. PPI deficits were antagonized by low doses of the preferential D2 antagonist L741626, supporting a D2 mechanism of action. Sumanirole is a valuable tool for parsing the role of dopamine receptor subtypes in the regulation of PPI.

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Conflict of interest statement

Conflict of interest: None

Figures

Fig. 1
Fig. 1. The effects of SUM (A-D), and APO or PRA (E) on PPI
(A)Time course of SUM effects. (B) Dose-response effects of SUM. (C) L741626 antagonized SUM-induced PPI deficits. (D) SUM decreased PPI at long prepulse intervals, but increased PPI at short prepulse intervals. (E) APO and PRA decreased PPI at long prepulse intervals, but PPI at short prepulse intervals was unaffected. * denotes significant differences for treatment with SUM, APO, or PRA vs. vehicle, & denotes significant antagonism of the SUM-induced PPI deficit by L741626; *,& p<0.05; ** p<0.005; ***,&&& p<0.0005.
See this image and copyright information in PMC

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