Review
doi: 10.1016/j.tibs.2010.02.009.
Epub 2010 Mar 24.
Polycomb group protein-mediated repression of transcription
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- PMID: 20346678
- DOI: 10.1016/j.tibs.2010.02.009
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Review
Polycomb group protein-mediated repression of transcription
Trends Biochem Sci.
2010 Jun.
Abstract
The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.
Copyright 2010 Elsevier Ltd. All rights reserved.
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