Seq-ing LPS-induced enhancers
- PMID: 20346768
- DOI: 10.1016/j.immuni.2010.03.011
Seq-ing LPS-induced enhancers
Abstract
In this issue of Immunity, Ghisletti et al. (2010) examined lipopolysaccharide (LPS)-induced binding of the p300 transcription coactivator to identify inducible enhancers throughout the genome of mouse macrophages, thereby revealing common features of enhancers that contribute to the LPS response and a critical role for PU.1 in enhancer marking.
Comment on
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Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages.Immunity. 2010 Mar 26;32(3):317-28. doi: 10.1016/j.immuni.2010.02.008. Epub 2010 Mar 4. Immunity. 2010. PMID: 20206554
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