Interleukin-18 in intestinal inflammation: friend and foe?
- PMID: 20346770
- DOI: 10.1016/j.immuni.2010.03.010
Interleukin-18 in intestinal inflammation: friend and foe?
Abstract
Genetic studies and other experimental data have linked inflammatory bowel diseases with inflammasome activation. In this issue of Immunity, Zaki et al. (2010) and Dupaul-Chicoine et al. (2010) provide a detailed characterization of the regulatory task of the inflammasome in intestinal epithelial cells.
Comment on
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Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases.Immunity. 2010 Mar 26;32(3):367-78. doi: 10.1016/j.immuni.2010.02.012. Epub 2010 Mar 11. Immunity. 2010. PMID: 20226691
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The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.Immunity. 2010 Mar 26;32(3):379-91. doi: 10.1016/j.immuni.2010.03.003. Epub 2010 Mar 18. Immunity. 2010. PMID: 20303296 Free PMC article.
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