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Comment
. 2010 Mar 26;32(3):302-4.
doi: 10.1016/j.immuni.2010.03.009.

Act1, scene brain: astrocytes play a lead role

Jane M Rodgers  1 , Liang Zhou, Stephen D Miller
Affiliations
Comment

Act1, scene brain: astrocytes play a lead role

Jane M Rodgers et al. Immunity. .

Abstract

Interleukin-17 (IL-17) is crucial for the progression of experimental autoimmune encephalomyelitis. In this issue of Immunity, Kang et al. (2010) report that neuroectoderm-derived astrocytes are the critical cellular element that responds to IL-17.

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Figures

Figure 1
Figure 1. IL-17-stimulated, Act1-dependent Stimulation of CNS Astrocytes is Required for Progression of EAE Via Chemokine-Mediated Recruitment of Peripheral Inflammatory Cells
Kang et al suggest a necessary role for astrocytes in EAE pathology. After activated myelin-specific Th17 cells infiltrate the CNS and are re-stimulated to produce IL-17, astrocytes respond via expression of IL-17R are stimulated to produce leukocyte attracting chemokines in an Act1-dependent manner. Astrocyte-derived chemokines then recruit a second wave of peripheral inflammatory cells, which mediate EAE progression via Th17cell -mediated bystander demyelination.
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References

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