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Review
. 2010 Apr;6(2):187-200.
doi: 10.1016/j.hfc.2009.11.001.

Atrial fibrillation in congestive heart failure

Steven A Lubitz  1 , Emelia J Benjamin, Patrick T Ellinor
Affiliations
Review

Atrial fibrillation in congestive heart failure

Steven A Lubitz et al. Heart Fail Clin. 2010 Apr.

Abstract

Atrial fibrillation and congestive heart failure are morbid conditions that have common risk factors and frequently coexist. Each condition predisposes to the other, and the concomitant presence of the two identifies individuals at increased risk for mortality. Recent data have emerged that help elucidate the complex genetic and nongenetic pathophysiological mechanisms that contribute to the development of atrial fibrillation in individuals with congestive heart failure. Clinical trial results offer insights into the noninvasive prevention and management of these conditions, although newer technologies, such as catheter ablation for atrial fibrillation, have yet to be studied extensively in patients with congestive heart failure.

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Figures

Figure 1
Figure 1
Mechanisms promoting atrial fibrillation in congestive heart failure. AF = atrial fibrillation, CHF = congestive heart failure
Figure 2
Figure 2
Genetic mutations affecting ionic currents that underlie the atrial action potential. ARP = atrial refractory period, GOF = gain of function mutation, LOF = loss of function mutation.
See this image and copyright information in PMC

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