In vitro methods to assess drug precipitation

Abstract

Drug precipitation in vivo is often an undesirable outcome after administration of a drug formulation into a human body. It may reduce drug concentration for immediate action, leading to a delayed or reduced efficacy. There are few practical in vivo assays available for evaluation of drug precipitation. Effective and efficient in vitro precipitation screening assays are highly desirable. In recent years, in vitro assays for assessment of drug precipitation potential have become available. The aim of this article is to provide the reader with a brief review of such in vitro precipitation screening assays for intravenous and oral formulations.