Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jan 14;14(1):65-9.
doi: 10.1007/BF00429710.

The metabolic fate of high density lipoprotein (HDL) in the diabetic rat

The metabolic fate of high density lipoprotein (HDL) in the diabetic rat

H Bar-On et al. Diabetologia. .

Abstract

Diabetic rats, pre-fed and maintained on a sucrose-rich diet, have marked hyperlipoproteinaemia, with an increase in both very low density (VLDL) and high density lipoproteins (HDL). HDL obtained from both diabetic and non-diabetic rats and labelled with 125I or 135I was injected simultaneously into diabetic and non-diabetic rats. The half life of the two HDL preparations was similar in both diabetic and non-diabetic rats and ranged between 11.4 to 12.0 hours. A-I apolipoprotein had a disappearance rate parallel to the whole HDL, in contrast to the apo-C peptides which had a faster rate of removal. Although the fractional catabolic rate (FCR) of HDL preparations was slower in the diabetic rats, there was a 16% increase in the calculated synthetic rate (SR) of HDL-protein. These observations could explain the increased plasma HDL levels in the sucrose-fed, streptozotocin-induced diabetic rat.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Lipid Res. 1972 Nov;13(6):757-68 - PubMed
    1. Diabetes. 1963 Mar-Apr;12:174-8 - PubMed
    1. Diabetes. 1966 Sep;15(9):675-9 - PubMed
    1. Phys Med Biol. 1957 Jul;2(1):36-53 - PubMed
    1. J Clin Invest. 1976 Mar;57(3):714-21 - PubMed

LinkOut - more resources