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. 2010 May 7;12(9):2150-3.
doi: 10.1021/ol1006696.

Total synthesis of (+)-decarbamoylsaxitoxin and (+)-gonyautoxin 3

Osamu Iwamoto  1 , Kazuo Nagasawa
Affiliations

Total synthesis of (+)-decarbamoylsaxitoxin and (+)-gonyautoxin 3

Osamu Iwamoto et al. Org Lett. .

Abstract

Facile construction of the complex saxitoxin (STX) skeleton is carried out by using a novel, conformationally controlled, guanidine cyclization process that relies on the use of neighboring group participation. The utility of this methodology is verified by its employment in syntheses of both natural and unnatural STX derivatives.

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