Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenation
- PMID: 20356402
- PMCID: PMC2861023
- DOI: 10.1186/1532-429X-12-20
Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenation
Abstract
Background: As myocardial oxygenation may serve as a marker for ischemia and microvascular dysfunction, it could be clinically useful to have a non-invasive measure of changes in myocardial oxygenation. However, the impact of induced blood flow changes on oxygenation is not well understood. We used oxygenation-sensitive CMR to assess the relations between myocardial oxygenation and coronary sinus blood oxygen saturation (SvO2) and coronary blood flow in a dog model in which hyperemia was induced by intracoronary administration of vasodilators.
Results: During administration of acetylcholine and adenosine, CMR signal intensity correlated linearly with simultaneously measured SvO2 (r2 = 0.74, P < 0.001). Both SvO2 and CMR signal intensity were exponentially related to coronary blood flow, with SvO2 approaching 87%.
Conclusions: Myocardial oxygenation as assessed with oxygenation-sensitive CMR imaging is linearly related to SvO2 and is exponentially related to vasodilator-induced increases of blood flow. Oxygenation-sensitive CMR may be useful to assess ischemia and microvascular function in patients. Its clinical utility should be evaluated.
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References
-
- Feigl EO. Coronary physiology. Physiol Rev. 1983;63:1–205. - PubMed
-
- McCommis KS, Goldstein TA, Abendschein DR, Herrero P, Misselwitz B, Gropler RJ, Zheng J. Quantification of regional myocardial oxygenation by magnetic resonance imaging: validation with positron emission tomography. Circ Cardiovasc Imaging. 2010;3:41–46. doi: 10.1161/CIRCIMAGING.109.897546. - DOI - PMC - PubMed
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