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Randomized Controlled Trial
. 2010 Nov;94(6):2385-8.
doi: 10.1016/j.fertnstert.2010.02.041. Epub 2010 Mar 31.

Metformin, naltrexone, or the combination of prednisolone and antiandrogenic oral contraceptives as first-line therapy in hyperinsulinemic women with polycystic ovary syndrome

Dijana Hadžiomerović-Pekić  1 , Ludwig Wildt, Jürgen Michael Weiss, Kay Moeller, Verena Mattle, Beata E Seeber
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Free article
Randomized Controlled Trial

Metformin, naltrexone, or the combination of prednisolone and antiandrogenic oral contraceptives as first-line therapy in hyperinsulinemic women with polycystic ovary syndrome

Dijana Hadžiomerović-Pekić et al. Fertil Steril. 2010 Nov.
Free article

Abstract

To compare the short-term effects of metformin (M), naltrexone (N), and a combination of OC and prednisolone (OC/Pr) on the metabolic state and the ovarian function of PCOS women, we randomized 29 women to a 3-month course of therapy. We observed significant improvements in hyperandrogenemia and ovulation rates in PCOS women of all three groups, in the absence of changes in the metabolic state, suggesting that insulin resistance in PCOS patients is only one of several factors leading to hyperandrogenemic ovarian failure.

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