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. 2010 Jun;67(2):207-8.
doi: 10.1016/j.diagmicrobio.2010.02.002. Epub 2010 Mar 31.

D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain

Andrés Antón  1 , María Angeles Marcos, Miguel Julián Martínez, Susana Ramón, Anna Martínez, Neus Cardeñosa, Pere Godoy, Nuria Torner, Patricia De Molina, Ricard Isanta, María Teresa Jiménez de Anta, Tomàs Pumarola
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D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain

Andrés Antón et al. Diagn Microbiol Infect Dis. 2010 Jun.

Abstract

From 27 April to 16 December 2009, we analyzed the hemagglutinin gene sequence of 2009 pandemic influenza A (H1N1) virus in 189 respiratory specimens. We only found the D225G mutation in 3 severe cases. However, it was not found in samples from other cases with or without clinical criteria of severity. The biologic significance of this mutation remains still unclear.

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